Issue 38, 2013
From the journal:

Chemical Communications

Development of a chemical probe for identifying protein targets of α-oxoaldehydes†

Christian Sibbersen,ab   Johan Palmfeldt,c   Jakob Hansen,b   Niels Gregersen,c   Karl Anker Jørgensena  and  Mogens Johannsen*b  

* Corresponding authors

a Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark
E-mail: kaj@chem.au.dk

b Department of Forensic Medicine, Bioanalytical Unit, Aarhus University, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark
E-mail: mj@forensic.au.dk
Tel: +45 87168332

c Research Unit for Molecular Medicine, Institute of Clinical Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark
E-mail: nig@ki.au.dk

Abstract

The development of a chemical probe for identifying the protein targets of reactive electrophilic α-oxoaldehydes such as methylglyoxal is presented. The probe is evaluated against methylglyoxal using human serum albumin as well as using living cells and lysates.

Graphical abstract: Development of a chemical probe for identifying protein targets of α-oxoaldehydes

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Article information

DOI
https://doi.org/10.1039/C3CC41099D
Article type
Communication
Submitted
08 Feb 2013
Accepted
24 Mar 2013
First published
25 Mar 2013

Chem. Commun., 2013,49, 4012-4014

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Development of a chemical probe for identifying protein targets of α-oxoaldehydes

C. Sibbersen, J. Palmfeldt, J. Hansen, N. Gregersen, K. A. Jørgensen and M. Johannsen, Chem. Commun., 2013, 49, 4012 DOI: 10.1039/C3CC41099D

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