Jump to main content
Jump to site search

Issue 36, 2013
Previous Article Next Article

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Author affiliations

Abstract

Tetrazinetrans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

Graphical abstract: Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Back to tab navigation

Supplementary files

Article information


Submitted
06 Feb 2013
Accepted
18 Mar 2013
First published
18 Mar 2013

Chem. Commun., 2013,49, 3805-3807
Article type
Communication

Development of a 11C-labeled tetrazine for rapid tetrazinetrans-cyclooctene ligation

M. M. Herth, V. L. Andersen, S. Lehel, J. Madsen, G. M. Knudsen and J. L. Kristensen, Chem. Commun., 2013, 49, 3805
DOI: 10.1039/C3CC41027G

Social activity

Search articles by author

Spotlight

Advertisements