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Issue 67, 2013
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Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

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Abstract

The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

Graphical abstract: Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

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Article information


Submitted
04 Feb 2013
Accepted
21 Jun 2013
First published
21 Jun 2013

Chem. Commun., 2013,49, 7415-7417
Article type
Communication

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

J. Fremaux, C. Dolain, B. Kauffmann, J. Clayden and G. Guichard, Chem. Commun., 2013, 49, 7415
DOI: 10.1039/C3CC40961A

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