Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization†
Abstract
Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of
* Corresponding authors
a
Medicinal Chemistry & Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
E-mail:
R.M.J.Liskamp@uu.nl
Fax: +31 30 253 6655
Tel: +31 30 253 7396/7307
b
Chemical Biology & Medicinal Chemistry, School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow, Scotland, UK
E-mail:
Robert.Liskamp@glasgow.ac.uk
Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of
J. Zhang, J. Kemmink, D. T. S. Rijkers and R. M. J. Liskamp, Chem. Commun., 2013, 49, 4498 DOI: 10.1039/C3CC40628H
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