Issue 32, 2013
From the journal:

Chemical Communications

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity†

Wolfgang Kandioller,*ab   Evelyn Balsano,a   Samuel M. Meier,ab   Ute Jungwirth,bc   Simone Göschl,a   Alexander Roller,a   Michael A. Jakupec,ab   Walter Berger,bc   Bernhard K. Kepplerab  and  Christian G. Hartinger*d  

* Corresponding authors

a University of Vienna, Institute of Inorganic Chemistry, Währinger Str. 42, 1090 Vienna, Austria
E-mail: wolfgang.kandioller@univie.ac.at
Fax: +43 1 4277 9526
Tel: +43 1 4277 52609

b University of Vienna, Research Platform “Translational Cancer Therapy Research”, Währinger Str. 42, A-1090 Vienna, Austria

c Medical University Vienna, Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, A-1090, Borschkegasse 8a, Vienna, Austria

d The University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand
E-mail: c.hartinger@auckland.ac.nz
Tel: +64 9 373 7955 ext. 83220

Abstract

Organometallic RuII, OsII and RhIII complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Graphical abstract: Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

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Article information

DOI
https://doi.org/10.1039/C3CC40432C
Article type
Communication
Submitted
18 Jan 2013
Accepted
06 Mar 2013
First published
06 Mar 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 3348-3350

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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

W. Kandioller, E. Balsano, S. M. Meier, U. Jungwirth, S. Göschl, A. Roller, M. A. Jakupec, W. Berger, B. K. Keppler and C. G. Hartinger, Chem. Commun., 2013, 49, 3348 DOI: 10.1039/C3CC40432C

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