Issue 15, 2013

Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development

Abstract

As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C12-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.

Graphical abstract: Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development

Supplementary files

Article information

Article type
Communication
Submitted
11 Dec 2012
Accepted
07 Jan 2013
First published
10 Jan 2013

Chem. Commun., 2013,49, 1515-1517

Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development

A. L. Garner, J. Yu, A. K. Struss, G. F. Kaufmann, V. V. Kravchenko and K. D. Janda, Chem. Commun., 2013, 49, 1515 DOI: 10.1039/C3CC38851D

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