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Issue 30, 2013
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TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

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Abstract

TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

Graphical abstract: TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

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Publication details

The article was received on 08 Dec 2012, accepted on 07 Jan 2013 and first published on 21 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38810G
Chem. Commun., 2013,49, 3101-3103

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    TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

    T. Terai, R. Tomiyasu, T. Ota, T. Ueno, T. Komatsu, K. Hanaoka, Y. Urano and T. Nagano, Chem. Commun., 2013, 49, 3101
    DOI: 10.1039/C3CC38810G

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