Issue 30, 2013
From the journal:

Chemical Communications

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1†

Takuya Terai,a   Rie Tomiyasu,a   Tomoe Ota,a   Tasuku Ueno,a   Toru Komatsu,a   Kenjiro Hanaoka,a   Yasuteru Urano*b  and  Tetsuo Nagano*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: tlong@mol.f.u-tokyo.ac.jp
Fax: +81-3-5841-4855
Tel: +81-3-5841-4850

b Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: uranokun@m.u-tokyo.ac.jp
Tel: +81-3-5841-3601

Abstract

TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

Graphical abstract: TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

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Article information

DOI
https://doi.org/10.1039/C3CC38810G
Article type
Communication
Submitted
08 Dec 2012
Accepted
07 Jan 2013
First published
21 Jan 2013

Chem. Commun., 2013,49, 3101-3103

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TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

T. Terai, R. Tomiyasu, T. Ota, T. Ueno, T. Komatsu, K. Hanaoka, Y. Urano and T. Nagano, Chem. Commun., 2013, 49, 3101 DOI: 10.1039/C3CC38810G

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