Issue 18, 2013

Heterocoupling of 2-naphthols enabled by a copper–N-heterocyclic carbene complex

Abstract

The reactivity of a Cu catalyst for oxidative coupling is modulated by a small molecule additive, diethyl malonate, that slows over-oxidation of 2-naphthols. Efficient heterocoupling between electron-rich and electron-poor 2-naphthols/2-naphthylamines affords C1-symmetric BINOLs with yields ranging from 35–98%.

Graphical abstract: Heterocoupling of 2-naphthols enabled by a copper–N-heterocyclic carbene complex

Supplementary files

Article information

Article type
Communication
Submitted
03 Dec 2012
Accepted
17 Jan 2013
First published
28 Jan 2013

Chem. Commun., 2013,49, 1835-1837

Heterocoupling of 2-naphthols enabled by a copper–N-heterocyclic carbene complex

M. Holtz-Mulholland, M. de Léséleuc and S. K. Collins, Chem. Commun., 2013, 49, 1835 DOI: 10.1039/C3CC38675A

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