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A new strategy towards [18F]trifluoromethyl-containing compounds is developed. [18F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [18F]trifluoromethyl carbinols in good yields.

Graphical abstract: Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers

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