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Issue 35, 2013
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The path for metal complexes to a DNA target

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The discovery of cisplatin as a therapeutic agent stimulated a new era in the application of transition metal complexes for therapeutic design. Here we describe recent results on a variety of transition metal complexes targeted to DNA to illustrate many of the issues involved in new therapeutic design. We describe first structural studies of complexes bound covalently and non-covalently to DNA to identify potential lesions within the cell. We then review the biological fates of these complexes, illustrating the key elements in obtaining potent activity, the importance of uptake and subcellular localization of the complexes, as well as the techniques used to delineate these characteristics. Genomic DNA provides a challenging but valuable target for new transition metal-based therapeutics.

Graphical abstract: The path for metal complexes to a DNA target

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Publication details

The article was received on 08 Jan 2013, accepted on 08 Feb 2013 and first published on 20 Feb 2013

Article type: Feature Article
DOI: 10.1039/C3CC00177F
Citation: Chem. Commun., 2013,49, 3617-3630

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    The path for metal complexes to a DNA target

    A. C. Komor and J. K. Barton, Chem. Commun., 2013, 49, 3617
    DOI: 10.1039/C3CC00177F

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