Issue 26, 2013
From the journal:

Chemical Communications

Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex†

S.-Ja. Tseng,‡a   Yi-Fang Zeng,‡b   Yu-Fan Deng,c   Pan-Chyr Yang,d   Je-Ruei Liu*bef  and  Ivan M. Kempson*ag  

* Corresponding authors

a Institute of Physics, Academia Sinica, Taipei 115, Taiwan

b Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
E-mail: jrliu@ntu.edu.tw

c Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 407, Taiwan

d Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan

e Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan

f Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan

g Ian Wark Research Institute, University of South Australia, Mawson Lakes, S.A., Australia
E-mail: Ivan.Kempson@unisa.edu.au
Fax: +61 8 8302 3683
Tel: +61 8 8302 3694

Abstract

A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.

Graphical abstract: Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

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Article information

DOI
https://doi.org/10.1039/C3CC00134B
Article type
Communication
Submitted
07 Jan 2013
Accepted
12 Feb 2013
First published
13 Feb 2013

Chem. Commun., 2013,49, 2670-2672

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Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

S.-Ja. Tseng, Y. Zeng, Y. Deng, P. Yang, J. Liu and I. M. Kempson, Chem. Commun., 2013, 49, 2670 DOI: 10.1039/C3CC00134B

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