Issue 13, 2013
From the journal:

Chemical Communications

Zn-mediated asymmetric allylation of N-tert-butanesulfinyl ketimines: an efficient and practical access to chiral quaternary 3-aminooxindoles†

Diao Chena  and  Ming-Hua Xu*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China
E-mail: xumh@mail.shcnc.ac.cn
Fax: +86 21 5080 7388
Tel: +86 21 5080 7388

Abstract

Room temperature zinc-mediated diastereoselective allylation or propargylation of isatin-derived N-tert-butanesulfinyl ketimines for synthesis of highly enantiomerically enriched tetrasubstituted 3-aminooxindoles is described.

Graphical abstract: Zn-mediated asymmetric allylation of N-tert-butanesulfinyl ketimines: an efficient and practical access to chiral quaternary 3-aminooxindoles

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Article information

DOI
https://doi.org/10.1039/C2CC38600C
Article type
Communication
Submitted
30 Nov 2012
Accepted
21 Dec 2012
First published
21 Dec 2012

Chem. Commun., 2013,49, 1327-1329

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Zn-mediated asymmetric allylation of N-tert-butanesulfinyl ketimines: an efficient and practical access to chiral quaternary 3-aminooxindoles

D. Chen and M. Xu, Chem. Commun., 2013, 49, 1327 DOI: 10.1039/C2CC38600C

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