Issue 3, 2013
From the journal:

Chemical Communications

Controlled β-protonation and [4+2] cycloaddition of enals and chalconesvia N-heterocyclic carbene/acid catalysis: toward substrate independent reaction control†

Zhenqian Fu,‡a   Hui Sun,‡b   Shaojin Chen,a   Bhoopendra Tiwari,a   Guohui Li*b  and  Yonggui Robin Chi*a  

* Corresponding authors

a Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore
E-mail: robinchi@ntu.edu.sg
Fax: +65 67911961
Tel: +65 65927769

b State key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Rd, Dalian, P. R. China
E-mail: ghli@dicp.ac.cn
Fax: +86 411-84675584
Tel: +86 411-84379593

Abstract

A substrate-independent selective generation of enolates over homoenolate equivalents in NHC-catalyzed reactions of enals and chalcones is disclosed. Acid co-catalysts play vital roles in control of the reaction pathways, allowing for individual access to diverse products from identical substrates.

Graphical abstract: Controlled β-protonation and [4+2] cycloaddition of enals and chalcones via N-heterocyclic carbene/acid catalysis: toward substrate independent reaction control

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Article information

DOI
https://doi.org/10.1039/C2CC36564B
Article type
Communication
Submitted
10 Sep 2012
Accepted
09 Nov 2012
First published
09 Nov 2012

Chem. Commun., 2013,49, 261-263

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Controlled β-protonation and [4+2] cycloaddition of enals and chalcones via N-heterocyclic carbene/acid catalysis: toward substrate independent reaction control

Z. Fu, H. Sun, S. Chen, B. Tiwari, G. Li and Y. Robin Chi, Chem. Commun., 2013, 49, 261 DOI: 10.1039/C2CC36564B

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