Issue 3, 2013
From the journal:

Chemical Communications

Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes†

Davinder Kumar,a   César A. Masitas,a   Tho N. Nguyena  and  Craig A. Grapperhaus*a  

* Corresponding authors

a Department of Chemistry, University of Louisville, Louisville, KY 40292, USA
E-mail: grapperhaus@louisville.edu
Fax: +1 502 852-8149
Tel: +1 502 852-5932

Abstract

A series of Ru(II) catalysts inspired by the metalloenzyme nitrile hydratase catalyze the hydration of benzonitrile with up to 242 turnovers under neutral conditions with very low catalysts loading. Catalysts with an oxidized sulfur environment are less susceptible to product inhibition increasing the catalytic efficiency at low nitrile : water ratios.

Graphical abstract: Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

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Article information

DOI
https://doi.org/10.1039/C2CC35256G
Article type
Communication
Submitted
20 Jul 2012
Accepted
14 Nov 2012
First published
16 Nov 2012

Chem. Commun., 2013,49, 294-296

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Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

D. Kumar, C. A. Masitas, T. N. Nguyen and C. A. Grapperhaus, Chem. Commun., 2013, 49, 294 DOI: 10.1039/C2CC35256G

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