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Issue 3, 2013
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Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

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Abstract

A series of Ru(II) catalysts inspired by the metalloenzyme nitrile hydratase catalyze the hydration of benzonitrile with up to 242 turnovers under neutral conditions with very low catalysts loading. Catalysts with an oxidized sulfur environment are less susceptible to product inhibition increasing the catalytic efficiency at low nitrile : water ratios.

Graphical abstract: Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

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Article information


Submitted
20 Jul 2012
Accepted
14 Nov 2012
First published
16 Nov 2012

Chem. Commun., 2013,49, 294-296
Article type
Communication

Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

D. Kumar, C. A. Masitas, T. N. Nguyen and C. A. Grapperhaus, Chem. Commun., 2013, 49, 294
DOI: 10.1039/C2CC35256G

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