Very bright europium complexes that stain cellular mitochondria

James W. Walton; Adrien Bourdolle; Stephen J. Butler; Marine Soulie; Martina Delbianco; Brian K. McMahon; Robert Pal; Horst Puschmann; Jurriaan M. Zwier; Laurent Lamarque; Olivier Maury; Chantal Andraud; David Parker

doi:10.1039/C2CC35247H

Very bright europium complexes that stain cellular mitochondria†

James W. Walton,^a Adrien Bourdolle,^b Stephen J. Butler,^a Marine Soulie,^c Martina Delbianco,^a Brian K. McMahon,^a Robert Pal,^a Horst Puschmann,^a Jurriaan M. Zwier,^c Laurent Lamarque,^c Olivier Maury,*^b Chantal Andraud^b and David Parker*^a

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^a Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: david.parker@dur.ac.uk
Fax: +44 (0)191 3844737
Tel: +44 (0)191 3342033

^b University of Lyon 1, ENS Lyon, CNRS - UMR 5182, 46 Allée d'Italie, 69364 Lyon, France
E-mail: olivier.maury@ens-lyon.fr

^c Cisbio Bioassays, Parc Marcel Boiteux, 30200 Codolet, France

Abstract

The synthesis, structure and photophysical properties of a series of highly emissive europium complexes is reported. Certain complexes enter mammalian cells by macropinocytosis and stain the mitochondria selectively, allowing observation of the Eu emission in cellulo by time-gated spectral imaging.

Chemical Communications

Very bright europium complexes that stain cellular mitochondria†

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Very bright europium complexes that stain cellular mitochondria

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