Issue 11, 2013
From the journal:

Biomaterials Science

Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel†

Juan Wu,‡a   Tian-Meng Sun,‡a   Xian-Zhu Yang,*ab   Jing Zhu,a   Xiao-Jiao Du,a   Yan-Dan Yao,c   Meng-Hua Xiong,a   Hong-Xia Wang,a   Yu-Cai Wanga  and  Jun Wang*a  

* Corresponding authors

a Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China
E-mail: jwang699@ustc.edu.cn
Fax: +86 551 63600402
Tel: +86 551 63600335

b School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China
E-mail: yangxz@hfut.edu.cn
Fax: +86 551 62905460
Tel: +86 551 62905460

c Department of Breast Surgery, No. 2 Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, People's Republic of China

Abstract

Effective systemic therapy is often necessary to treat hepatocellular carcinoma (HCC). We synthesized a Gal-PPE nanogel consisting of a cross-linked polyphosphate core and galactosylated poly(ethylene glycol) arms for enhanced doxorubicin delivery to diethylnitrosamine-induced HCC in rats. The Gal-PPE nanogel exhibited high affinity to HepG2 cells in vitro, mediated by the asialoglycoprotein receptor. In vivo studies revealed that the Gal-PPE nanogel was taken up more efficiently by hepatocytes, in contrast to m-PPE nanogel. Consequently, doxorubicin delivery with Gal-PPE significantly inhibited the progress of HCC, reducing neoplastic liver nodules and prolonging the survival time of HCC rats more significantly. These results demonstrate the potential of Gal-PPE as a nanocarrier for improved HCC chemotherapy.

Graphical abstract: Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel

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Article information

DOI
https://doi.org/10.1039/C3BM60099H
Article type
Paper
Submitted
16 Apr 2013
Accepted
06 Jun 2013
First published
17 Jul 2013

Biomater. Sci., 2013,1, 1143-1150

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Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel

J. Wu, T. Sun, X. Yang, J. Zhu, X. Du, Y. Yao, M. Xiong, H. Wang, Y. Wang and J. Wang, Biomater. Sci., 2013, 1, 1143 DOI: 10.1039/C3BM60099H

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