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Issue 22, 2013
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Equilibrium distribution sampling device for preparation of calibration mixtures for gas chromatography-mass spectrometry

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Abstract

A simple approach for preparing standard mixtures of volatile and semi-volatile organic compounds is reported. When placed in a closed container, standard mixture components partition between a polymeric material such as poly(dimethylsiloxane) (PDMS) and headspace to provide constant vapor concentrations. The granular form of heat-conditioned PDMS provides rapid equilibration with the headspace vapor and serves as a standard reservoir. Solid phase micro extraction (SPME) or gas-tight syringe can be used to deliver sample from the headspace to the analytical instrument. Quantitative calibration can be achieved with either active temperature control or by using a previously constructed look-up table. The effects of PDMS form and temperature on equilibrium distribution, initial equilibrium time, and re-equilibrium time after sampling were investigated. With respect to long term use and stability, analytes introduced onto 2.0 g of PDMS in a 7.4 mL vial were sampled more than 114 times during a test period of 43 days, giving chromatographic peak area %RSD values below 4.5% for all compounds. This device was designed to be solventless, quantitative, reproducible, environmentally friendly, and robust for routine evaluation and calibration of gas chromatography-mass spectrometry (GC-MS) systems.

Graphical abstract: Equilibrium distribution sampling device for preparation of calibration mixtures for gas chromatography-mass spectrometry

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Supplementary files

Article information


Submitted
14 Aug 2013
Accepted
20 Sep 2013
First published
20 Sep 2013

Anal. Methods, 2013,5, 6312-6318
Article type
Paper

Equilibrium distribution sampling device for preparation of calibration mixtures for gas chromatography-mass spectrometry

X. Xie, T. V. Truong, J. A. Murray, J. A. Contreras, H. D. Tolley and M. L. Lee, Anal. Methods, 2013, 5, 6312
DOI: 10.1039/C3AY41393D

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