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Issue 20, 2013
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A water-soluble and specific BODIPY-based fluorescent probe for hypochlorite detection and cell imaging

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Abstract

Hypochlorite is one of the biologically important reactive oxygen species (ROS). Herein, a BODIPY-based fluorescent probe (BOD-OXIME) has been designed and synthesized for fluorescence detection of hypochlorite in aqueous media and imaging in live cells. Incorporating hydrophilic carboxyl and hydroxyl moieties makes the probe BOD-OXIME highly water soluble, thus making it operable in totally aqueous media. Besides, the probe can respond quickly toward hypochlorite in aqueous media. This new probe exhibits high selectivity and sensitivity towards ClO over other reactive oxygen species (ROS) and reactive nitrogen species (RNS). Furthermore, the probe BOD-OXIME can be successfully applied to image both exogenous and endogenous ClO in living cells.

Graphical abstract: A water-soluble and specific BODIPY-based fluorescent probe for hypochlorite detection and cell imaging

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Publication details

The article was received on 28 Jul 2013, accepted on 23 Aug 2013 and first published on 23 Aug 2013


Article type: Paper
DOI: 10.1039/C3AY41268G
Anal. Methods, 2013,5, 5589-5596

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    A water-soluble and specific BODIPY-based fluorescent probe for hypochlorite detection and cell imaging

    G. Wu, F. Zeng and S. Wu, Anal. Methods, 2013, 5, 5589
    DOI: 10.1039/C3AY41268G

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