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Issue 16, 2013
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Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry

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Abstract

Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMS-selected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level.

Graphical abstract: Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry

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Article information


Submitted
23 Apr 2013
Accepted
10 Jul 2013
First published
11 Jul 2013

Anal. Methods, 2013,5, 3799-3802
Article type
Communication

Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry

R. W. Smith, J. C. Reynolds, S. Lee and C. S. Creaser, Anal. Methods, 2013, 5, 3799
DOI: 10.1039/C3AY40676H

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