Nonenzymatic glucose sensor based on three different CuO nanomaterials

Abstract

A non-enzymatic glucose biosensor was constructed by immobilizing three different nanostructures of CuO (nanoparticles, nanoplatelets, nanorods), respectively, on a glassy carbon electrode (GCE) with Nafion. Compared with the bare GCE, the modified electrodes exhibited excellent catalysis to direct glucose oxidation. An electrochemical study showed that CuO nanoparticles exhibited the highest catalytic effect on glucose oxidation compared to CuO nanorods or nanoplatelets. This can be attributed to the fast electron transfer ability and highly specific surface area of the nanoparticles. Amperometric response showed that the CuO nanoparticle-modified electrode had a good response for glucose with a linear range up to 6 mM CuO and a sensitivity of 1.43 mA cm⁻² mM⁻¹ in 0.2 M NaOH. Detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA) was carried out using these CuO modified electrodes, the results indicated good selectivity for glucose detection.