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Issue 17, 2013
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Dumbbell-shaped stir bar coated with dendrimer-based MIPs for selective extraction and analysis of vardenafil and its analogue sildenafil in health foods

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Abstract

A novel dendrimer-based molecularly imprinted polymers (MIPs) coated dumbbell-shaped stir bar (DSB) was developed to enrich and analyze two kinds of phosphodiesterase type 5 (PDE-5) inhibitors in health foods (Hfs). The MIPs, with vardenafil as the template molecule and methacrylic acid (MAA) as the functional monomer, were synthesized on the surface of the dendritic-grafting DSB which was filled with magnetic core as substrate. The MIPs-DSB possessed mechanical stability, high adsorption capacity and good selectivity for vardenafil and its analogue sildenafil. A method for the determination of vardenafil and sildenafil in Hfs was established by stir bar sorptive extraction (SBSE) coupled with HPLC-UV. The contents of vardenafil and sildenafil were found to be 3.65 and 2.66 μg g−1, respectively, and the average recoveries in spiked Hfs were 86.5–91.8% with a relative standard deviation (RSD) below 5%. All results revealed that the MIPs-DSB coupled with HPLC-UV could be applied to the highly selective extraction and sensitive determination of trace analytes in a complex matrix.

Graphical abstract: Dumbbell-shaped stir bar coated with dendrimer-based MIPs for selective extraction and analysis of vardenafil and its analogue sildenafil in health foods

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Publication details

The article was received on 04 Feb 2013, accepted on 15 Jun 2013 and first published on 17 Jun 2013


Article type: Paper
DOI: 10.1039/C3AY40211H
Anal. Methods, 2013,5, 4494-4500

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    Dumbbell-shaped stir bar coated with dendrimer-based MIPs for selective extraction and analysis of vardenafil and its analogue sildenafil in health foods

    Y. Wang, J. Wu, C. Xue, R. Wang, T. Wen, J. Hong, Q. Hu, F. Li and X. Zhou, Anal. Methods, 2013, 5, 4494
    DOI: 10.1039/C3AY40211H

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