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Issue 1, 2013
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Comparison of anti-fouling surface coatings for applications in bacteremia diagnostics

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Abstract

To accurately diagnose microbial infections in blood, it is essential to recover as many microorganisms from a sample as possible. Unfortunately, recovery of such microorganisms depends significantly on their adhesion to the surfaces of diagnostic devices. Consequently, we sought to minimize the adhesion of methicillin-sensitive Staphylococcus aureus (MSSA) to the surface of polypropylene- and acrylic-based bacteria concentration devices. These devices were treated with 11 different coatings having various charges and hydrophobicities. Some coatings promoted bacterial adhesion under centrifugation, whereas others were more likely to prevent it. Experiments were run using a simple buffer system and lysed blood, both inoculated with MSSA. Under both conditions, Hydromer's 7-TS-13 and Aqua 65JL were most effective in reducing bacterial adhesion.

Graphical abstract: Comparison of anti-fouling surface coatings for applications in bacteremia diagnostics

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Publication details

The article was received on 26 Jun 2012, accepted on 10 Oct 2012 and first published on 11 Oct 2012


Article type: Technical Note
DOI: 10.1039/C2AY25662B
Citation: Anal. Methods, 2013,5, 273-280

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    Comparison of anti-fouling surface coatings for applications in bacteremia diagnostics

    A. K. Boardman, S. Allison, A. Sharon and A. F. Sauer-Budge, Anal. Methods, 2013, 5, 273
    DOI: 10.1039/C2AY25662B

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