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Issue 11, 2013
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Applications of ambient mass spectrometry in high-throughput screening

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Abstract

The development of rapid screening and identification techniques is of great importance for drug discovery, doping control, forensic identification, food safety and quality control. Ambient mass spectrometry (AMS) allows rapid and direct analysis of various samples in open air with little sample preparation. Recently, its applications in high-throughput screening have been in rapid progress. During the past decade, various ambient ionization techniques have been developed and applied in high-throughput screening. This review discusses typical applications of AMS, including DESI (desorption electrospray ionization), DART (direct analysis in real time), EESI (extractive electrospray ionization), etc., in high-throughput screening (HTS).

Graphical abstract: Applications of ambient mass spectrometry in high-throughput screening

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Publication details

The article was received on 16 Jan 2013, accepted on 13 Mar 2013 and first published on 14 Mar 2013


Article type: Minireview
DOI: 10.1039/C3AN00119A
Citation: Analyst, 2013,138, 3097-3103
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    Applications of ambient mass spectrometry in high-throughput screening

    L. Li, B. Feng, J. Yang, C. Chang, Y. Bai and H. Liu, Analyst, 2013, 138, 3097
    DOI: 10.1039/C3AN00119A

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