We describe a novel ‘switch-off’ biosensing strategy for the detection of chymotrypsin based on surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) spectroscopy. This approach analyzes the fingerprint spectrum of the chymotrypsin-catalyzed substrate. The lowest probed concentration is 0.4 nM for chymotrypsin.
C. Fu, W. Xu, G. Chen and S. Xu, Analyst, 2013, 138, 6282 DOI: 10.1039/C3AN01427D
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