Issue 12, 2013
From the journal:

Analyst

A novel fluorescent “Turn-Off/Turn-On” system for the detection of acid phosphatase activity†

Pu Guo,‡a   Shengyong Yan,‡a   Yimin Zhou,a   Changcheng Wang,a   Xiaowei Xu,a   Xiaocheng Wenga  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: xzhou@whu.edu.cn
Fax: +86-27-87336380
Tel: +86-27-61056559

b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, P. R. China

Abstract

Acid phosphatase (ACP) can be sensitively, conveniently and efficiently detected via a new fluorescent “Turn-Off/Turn-On” system. Inexpensive (NaPO3)6 is carefully introduced into this system as a quencher of the aggregation-caused quenching (ACQ) probe. In our method, the limit of detection (LOD) is quite low for detecting ACP, which is an important biomarker and indication of several diseases.

Graphical abstract: A novel fluorescent “Turn-Off/Turn-On” system for the detection of acid phosphatase activity

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C3AN00375B
Article type
Communication
Submitted
21 Feb 2013
Accepted
25 Mar 2013
First published
25 Mar 2013

Analyst, 2013,138, 3365-3367

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A novel fluorescent “Turn-Off/Turn-On” system for the detection of acid phosphatase activity

P. Guo, S. Yan, Y. Zhou, C. Wang, X. Xu, X. Weng and X. Zhou, Analyst, 2013, 138, 3365 DOI: 10.1039/C3AN00375B

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