Issue 10, 2013
From the journal:

Analyst

Extremely selective “turn-on” fluorescence detection of hypochlorite confirmed by proof-of-principle neurological studies via esterase action in living cells†

Atul P. Singh,a   Olga G. Tsay,a   Dhiraj P. Murale,a   Taehong Jun,a   Hyunjeong Liew,b   Yoo-Hun Suhb  and  David G. Churchill*a  

* Corresponding authors

a Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea
E-mail: dchurchill@kaist.ac.kr

b Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer's Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul 110-799, Republic of Korea

Abstract

Highly specific and sensitive fluorescence detection of hypochlorite in nonbiotic pure water (rapid “turn-on”, ∼400 fold, λem ∼ 560 nm) as well as in living neuronal cell cultures (neutral pH) involves oxidation of a 2-sulfide-2-benzoic acid pendent group in a new meso-thienyl-BODIPY donor–acceptor probe.

Graphical abstract: Extremely selective “turn-on” fluorescence detection of hypochlorite confirmed by proof-of-principle neurological studies via esterase action in living cells

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Article information

DOI
https://doi.org/10.1039/C3AN00297G
Article type
Communication
Submitted
09 Feb 2013
Accepted
25 Mar 2013
First published
26 Mar 2013

Analyst, 2013,138, 2829-2832

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Extremely selective “turn-on” fluorescence detection of hypochlorite confirmed by proof-of-principle neurological studies via esterase action in living cells

A. P. Singh, O. G. Tsay, D. P. Murale, T. Jun, H. Liew, Y. Suh and D. G. Churchill, Analyst, 2013, 138, 2829 DOI: 10.1039/C3AN00297G

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