Issue 1, 2012

Mechanisms and modifiers of methylmercury-induced neurotoxicity


The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided mechanistic insights into the contribution of genetic and environmental factors that interact with MeHg to modify toxicity. This review will outline cellular processes directly and indirectly affected by MeHg, including oxidative stress, cellular signaling and gene expression, and discuss epigenetic modifications, genetic polymorphisms and gene–environment interactions capable of modifying MeHg neurotoxicity.

Graphical abstract: Mechanisms and modifiers of methylmercury-induced neurotoxicity

Article information

Article type
Review Article
30 Jan 2012
02 May 2012
First published
02 May 2012

Toxicol. Res., 2012,1, 32-38