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Issue 24, 2012
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Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

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Abstract

We demonstrate that recently observed increases in cell permeation activity of cyclic peptides via transporter sequences are due to the underlying phase behavior of peptide–lipid complexes and their relation to the topological requirement of membrane permeation. We also show how these effects can be amplified by incorporating hydrophobicity in these sequences.

Graphical abstract: Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

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Publication details

The article was received on 22 Feb 2012, accepted on 13 Apr 2012 and first published on 18 May 2012


Article type: Communication
DOI: 10.1039/C2SM25405K
Citation: Soft Matter, 2012,8, 6430-6433
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    Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

    K. Zhao, U. Choe, D. T. Kamei and G. C. L. Wong, Soft Matter, 2012, 8, 6430
    DOI: 10.1039/C2SM25405K

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