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Issue 14, 2012
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Giant amyloid spherulites reveal their true colours§

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Abstract

The prevalence of degenerative conditions such as Alzheimer's and Parkinson's disease amongst an increasingly elderly population has led to substantial research efforts into understanding the properties and structures of amyloid protein aggregates. One such aggregate, the amyloid spherulite, consists of a central core surrounded by long fibres of aggregated protein (fibrils) which grow radially outwards. Spherulites (5–50 μm in diameter) exhibit four white lobes when observed using crossed polarised microscopy, due to their birefringence. Here we report the growth of giant amyloid spherulites (GAS, diameters 0.4–1 mm) that produce colourful patterns when placed between crossed polarisers. A ray tracing model was developed that accounts for these patterns by calculating the effects of birefringence on light passing through the GAS. This new model links for the first time the optical properties of spherulites to the density and orientation of the fibrils, providing a route to understanding the formation of these important protein aggregates.

Graphical abstract: Giant amyloid spherulites reveal their true colours

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Article information


Submitted
19 Jan 2012
Accepted
30 Jan 2012
First published
14 Feb 2012

Soft Matter, 2012,8, 3751-3755
Article type
Paper

Giant amyloid spherulites reveal their true colours

M. I. Smith, J. S. Sharp and C. J. Roberts, Soft Matter, 2012, 8, 3751
DOI: 10.1039/C2SM25147G

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