Issue 41, 2012

Margination and segregation in confined flows of blood and other multicomponent suspensions

Abstract

Blood and many other multicomponent suspensions display a segregation behavior in which different components of the suspension are differentially distributed in the cross-stream direction during flow in a confined geometry such as an arteriole or a microfluidic device. Specifically, in blood the platelets and leukocytes are strongly segregated to the near-wall region and are said to be “marginated”. The present work reviews segregation phenomena in multicomponent suspensions. Well-established results on migration and shear-induced diffusion in single-component suspensions are followed by results on binary suspensions of rigid spheres. Then the primary experimental and computational observations are presented for blood and related systems. The final part of the review presents an overview of modeling approaches that attempt to incorporate the physical mechanisms underlying transport phenomena in suspensions into mathematical models – the limited degree of success attained by these models for multicomponent systems is described.

Graphical abstract: Margination and segregation in confined flows of blood and other multicomponent suspensions

Article information

Article type
Review Article
Submitted
23 Apr 2012
Accepted
24 May 2012
First published
14 Jun 2012

Soft Matter, 2012,8, 10536-10548

Margination and segregation in confined flows of blood and other multicomponent suspensions

A. Kumar and M. D. Graham, Soft Matter, 2012, 8, 10536 DOI: 10.1039/C2SM25943E

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