Issue 18, 2012
From the journal:

Soft Matter

Supramolecular hydrogels based on antimycobacterial amphiphiles†

Andreas Bernet,*a   Marina Behra  and  Hans-Werner Schmidt*a  

* Corresponding authors

a Macromolecular Chemistry I, Bayreuther Institut für Makromolekülforschung (BIMF), Bayreuther Zentrum für Kolloide und Grenzflächen (BZKG), University of Bayreuth, D-95440 Bayreuth, Germany
E-mail: andreas.bernet@uni-bayreuth.de, hans-werner.schmidt@uni-bayreuth.de
Fax: +49 (0)921 553206
Tel: +49 (0)921 553200

Abstract

Synthetic modification of antimycobacterial 4-alkoxy-anilines yields low molecular weight amphiphiles. The bioactivity is retained in these amphiphiles and shows alkyl chain length specificity. The self-assembly behaviour in aqueous media was investigated. It was found that several of these new compounds are capable of forming thermoreversible supramolecular hydrogels in alkaline aqueous media. The initial drug can be released from the hydrogel by thermal hydrolysis.

Graphical abstract: Supramolecular hydrogels based on antimycobacterial amphiphiles

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Article information

DOI
https://doi.org/10.1039/C2SM07456G
Article type
Communication
Submitted
23 Dec 2011
Accepted
15 Mar 2012
First published
29 Mar 2012

Soft Matter, 2012,8, 4873-4876

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Supramolecular hydrogels based on antimycobacterial amphiphiles

A. Bernet, M. Behr and H. Schmidt, Soft Matter, 2012, 8, 4873 DOI: 10.1039/C2SM07456G

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