Issue 1, 2012

Surface adsorption of fibronectin-derived peptide fragments: the influence of electrostatics and hydrophobicity for endothelial cells adhesion

Abstract

The adsorption on hydrophobic and hydrophilic silica-based surfaces of the integrin-binding PHSRN peptide and the single-residual-mutated analogues, PHSEN and PHSFN, is investigated by comparative QCM-D, XPS, SFG measurements and molecular dynamics calculations. Endothelial cell cultures on the peptide-functionalized materials highlight their tunable pro- or anti-angiogenic potential.

Graphical abstract: Surface adsorption of fibronectin-derived peptide fragments: the influence of electrostatics and hydrophobicity for endothelial cells adhesion

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug 2011
Accepted
27 Oct 2011
First published
11 Nov 2011

Soft Matter, 2012,8, 53-56

Surface adsorption of fibronectin-derived peptide fragments: the influence of electrostatics and hydrophobicity for endothelial cells adhesion

C. Satriano, M. E. Fragalà, G. Forte, A. M. Santoro, D. La Mendola and B. Kasemo, Soft Matter, 2012, 8, 53 DOI: 10.1039/C1SM06655B

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