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Issue 12, 2012
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Interaction of spermine-alanine functionalized perylene bisimide dye aggregates with ds-DNA/RNA secondary structure

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Abstract

We report for the first time on the interaction of self-assembled perylene bisimide (PBI) dye aggregates with polynucleotides, revealing very high (nM) binding constants and exceptional thermal stabilization of double-stranded (ds)-DNA/RNA. Induced CD profiles of PBI dimer aggregates formed within DNA/RNA grooves show high sensitivity on the steric properties of the binding site, suggesting the applicability of such self-adjusting excitonically coupled PBI dimers for the sensing of the DNA/RNA secondary structure.

Graphical abstract: Interaction of spermine-alanine functionalized perylene bisimide dye aggregates with ds-DNA/RNA secondary structure

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Publication details

The article was received on 27 Jun 2012, accepted on 23 Aug 2012 and first published on 24 Aug 2012


Article type: Edge Article
DOI: 10.1039/C2SC20825C
Chem. Sci., 2012,3, 3393-3397

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    Interaction of spermine-alanine functionalized perylene bisimide dye aggregates with ds-DNA/RNA secondary structure

    T. H. Rehm, M. R. Stojković, S. Rehm, M. Škugor, I. Piantanida and F. Würthner, Chem. Sci., 2012, 3, 3393
    DOI: 10.1039/C2SC20825C

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