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Issue 2, 2012
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A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems

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Abstract

Reduced nitrogen oxide ligands such as NO/HNO or nitroxyl participate in chemistry distinct from nitric oxide (NO). Nitroxyl has been proposed to form at heme centers to generate the Enemark–Feltham designated {FeNO}8 system. The synthesis of a thermally stable {FeNO}8 species namely, [Co(Cp*)2][Fe(LN4)(NO)] (3), housed in a heme-like ligand platform has been achieved by reduction of the corresponding {FeNO}7 complex, [Fe(LN4)(NO)] (1), with decamethylcobaltocene [Co(Cp*)2] in toluene. This complex readily reacts with metMb, resulting in formation of MbNO via reductive nitrosylation by the coordinated HNO/NO, which can be inhibited with GSH. These results suggest that 3 could serve as a potential HNO therapeutic. Spectroscopic, theoretical, and structural comparisons are made to 1 and the {CoNO}8 complex, [Co(LN4)(NO)] (2), an isoelectronic analogue of 3.

Graphical abstract: A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems

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Article information


Submitted
21 Aug 2011
Accepted
13 Sep 2011
First published
06 Oct 2011

Chem. Sci., 2012,3, 364-369
Article type
Edge Article

A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems

A. K. Patra, K. S. Dube, B. C. Sanders, G. C. Papaefthymiou, J. Conradie, A. Ghosh and T. C. Harrop, Chem. Sci., 2012, 3, 364
DOI: 10.1039/C1SC00582K

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