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Issue 1, 2012
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Structural and kinetic study of self-assembling macrocyclic dimer natural product aminoglycoside66-40C and unnatural variants

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Abstract

Aminoglycoside 66-40C, co-produced with antibiotic sisomicin by Micromonospora inyoensis is unique among natural products, featuring a 16-membered macrocyclic bis-imine (X-ray) stable in aqueous solution and produced by quantitative self-assembly from self-selecting condensation of 6′-aldehyde monomers, in complex mixtures and in the presence of competing amine and aldehyde substrates.

Graphical abstract: Structural and kinetic study of self-assembling macrocyclic dimer natural product aminoglycoside66-40C and unnatural variants

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Article information


Submitted
05 Aug 2011
Accepted
25 Aug 2011
First published
23 Sep 2011

Chem. Sci., 2012,3, 249-256
Article type
Edge Article

Structural and kinetic study of self-assembling macrocyclic dimer natural product aminoglycoside66-40C and unnatural variants

S. Hanessian, J. P. Maianti, V. L. Ly and B. Deschênes-Simard, Chem. Sci., 2012, 3, 249
DOI: 10.1039/C1SC00538C

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