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Issue 13, 2012
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Metal-free pinnick-type oxidative amidation of aldehydes

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Abstract

A metal-free Pinnick-type oxidative amidation of aldehyde has been developed. Sodium chlorite was found to be a useful oxidant in coupling an aldehyde and amine to form an amide bond. A large variety of substrates are suitable and many functional groups are tolerated due to the mild nature of this amidation methodology. Optically active substrates were coupled smoothly with good yield and without racemization. As inexpensive reagents were used, it is cost effective even on a larger scale, indicating its potential for practical application.

Graphical abstract: Metal-free pinnick-type oxidative amidation of aldehydes

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Publication details

The article was received on 25 Apr 2012, accepted on 26 Apr 2012 and first published on 28 May 2012


Article type: Communication
DOI: 10.1039/C2RA20773G
Citation: RSC Adv., 2012,2, 5536-5538
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    Metal-free pinnick-type oxidative amidation of aldehydes

    K. S. Goh and C. Tan, RSC Adv., 2012, 2, 5536
    DOI: 10.1039/C2RA20773G

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