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Issue 13, 2012
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Application of a multi-SO3H Brønsted acidic ionic liquid in water: a highly efficient and reusable catalyst for the regioselective and scaled-up synthesis of pyrazoles under mild conditions

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Abstract

An elegant and efficient procedure with exceptionally mild conditions for the regioselective synthesis of pyrazoles by the reaction of various 1,3-diketones and hydrazines/hydrazides using a multi-SO3H Brønsted acidic room temperature ionic liquid as a powerful catalyst in aqueous media has been developed. The ionic liquid was easily separated from the reaction mixture and was recycled and used for at least six consecutive runs without any loss of activity.

Graphical abstract: Application of a multi-SO3H Brønsted acidic ionic liquid in water: a highly efficient and reusable catalyst for the regioselective and scaled-up synthesis of pyrazoles under mild conditions

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Publication details

The article was received on 04 Apr 2012, accepted on 05 Apr 2012 and first published on 11 Apr 2012


Article type: Paper
DOI: 10.1039/C2RA20624B
Citation: RSC Adv., 2012,2, 5610-5616
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    Application of a multi-SO3H Brønsted acidic ionic liquid in water: a highly efficient and reusable catalyst for the regioselective and scaled-up synthesis of pyrazoles under mild conditions

    S. Safaei, I. Mohammadpoor-Baltork, A. R. Khosropour, M. Moghadam, S. Tangestaninejad, V. Mirkhani and R. Kia, RSC Adv., 2012, 2, 5610
    DOI: 10.1039/C2RA20624B

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