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Issue 11, 2012
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Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

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Abstract

Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.

Graphical abstract: Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

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Article information


Submitted
10 Nov 2011
Accepted
23 Jan 2012
First published
07 Mar 2012

RSC Adv., 2012,2, 4547-4592
Article type
Review Article

Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

M. S. Singh and S. Chowdhury, RSC Adv., 2012, 2, 4547
DOI: 10.1039/C2RA01056A

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