Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 6, 2012
Previous Article Next Article

ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility

Author affiliations

Abstract

Nanotechnology is providing new ways to manipulate the structure and chemistry of surfaces to inhibit bacterial colonization. In this study, we evaluated the ability of glass slides coated with zinc oxide (ZnO) nanoparticles to restrict the biofilm formation of common bacterial pathogens. The generation of hydroxyl radicals, originating from the coated surface, was found to play a key role in antibiofilm activity. Furthermore, we evaluated the ability of the nanoparticle coating to enhance the antibacterial activity of commonly-used antibiotics. The ZnO nanoparticles were synthesized and deposited on the surface of glass slides using a one-step ultrasound irradiation process. Several physico-chemical surface characterization methods were performed to prove the long-term stability and homogenity of the coated films. Collectively, our findings may open a new door for utilizing ZnO nanoparticle films as antibiofilm coating of surfaces, thus providing a versatile platform for a wide range of applications both in medical and industrial settings, all of which are prone to bacterial colonization.

Graphical abstract: ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility

Back to tab navigation

Supplementary files

Article information


Submitted
17 Aug 2011
Accepted
04 Dec 2011
First published
26 Jan 2012

RSC Adv., 2012,2, 2314-2321
Article type
Paper

ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility

G. Applerot, J. Lellouche, N. Perkas, Y. Nitzan, A. Gedanken and E. Banin, RSC Adv., 2012, 2, 2314
DOI: 10.1039/C2RA00602B

Social activity

Search articles by author

Spotlight

Advertisements