Issue 24, 2012
From the journal:

RSC Advances

Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates†

Dong Sheng Lee,ab   Pui Ying Choy,a   Chau Ming So,a   Jun Wang,a   Chak Po Laua  and  Fuk Yee Kwong*a  

* Corresponding authors

a State Key Laboratory of Chirosciences and PolyU Shenzhen Research Institute (SZRI), Shenzhen; and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
E-mail: fuk-yee.kwong@polyu.edu.hk
Fax: (+) 852-2364-9932

b Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan R.O.C.

Abstract

This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C–H bond functionalization/C–N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.

Graphical abstract: Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

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Article information

DOI
https://doi.org/10.1039/C2RA21667A
Article type
Paper
Submitted
01 Aug 2012
Accepted
02 Aug 2012
First published
02 Aug 2012

RSC Adv., 2012,2, 9179-9182

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Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

D. S. Lee, P. Y. Choy, C. M. So, J. Wang, C. P. Lau and F. Y. Kwong, RSC Adv., 2012, 2, 9179 DOI: 10.1039/C2RA21667A

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