Issue 31, 2012
From the journal:

RSC Advances

Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

Chandran Raju,a   Kalaipriya Madhaiyan,b   Ramakrishnan Uma,a   Radhakrishnan Sridhar*b  and  Seeram Ramakrishnab  

* Corresponding authors

a Pachaiyappa’s College, University of Madras, Aminjikarai, Chennai 600 029, India
Tel: +91-9902100665

b NUSCNN Lab National University of Singapore, Singapore
Fax: 65-6773 0339
Tel: +65 97165929

Abstract

A simple, efficient and economic synthesis of tetrazolo [1,5-a]pyrimidine-6-carboxylates was accomplished by three-component reaction of β-ketoesters with a mixture of aromatic aldehyde and 5-aminotetrazole using TFA:DIPEA (1 : 1) as the catalyst. The synthesized tetrazole compounds are evaluated for their antimicrobial and antioxidant activity.

Graphical abstract: Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

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Article information

DOI
https://doi.org/10.1039/C2RA21330C
Article type
Communication
Submitted
01 Jul 2012
Accepted
28 Sep 2012
First published
01 Oct 2012

RSC Adv., 2012,2, 11657-11663

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Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

C. Raju, K. Madhaiyan, R. Uma, R. Sridhar and S. Ramakrishna, RSC Adv., 2012, 2, 11657 DOI: 10.1039/C2RA21330C

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