Issue 18, 2012
From the journal:

RSC Advances

Palladium-catalysed direct regiospecific arylation at C5 of thiophenes bearing SO2R substituents at C3

Charles Beromeo Bheeter,a   Jitendra K. Berab  and  Henri Doucet*a  

* Corresponding authors

a Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes “Catalyse et Organométalliques”, 35042 Rennes, France
E-mail: henri.doucet@univ-rennes1.fr
Tel: +33 (0)2 23 23 63 84

b Department of Chemistry, Indian Institute of Technology Kanpur, 208016 Kanpur, India

Abstract

The palladium catalysed direct arylation of thiophenes substituted at C3 by SO2R subtituents was found to be fully selective in favor of carbon C5. This reaction allows the synthesis of a wide variety of 5-aryl-3-sulfonic acid derivatives using as little as 0.5–1 mol% of Pd(OAc)2 as the catalyst in only one step.

Graphical abstract: Palladium-catalysed direct regiospecific arylation at C5 of thiophenes bearing SO2R substituents at C3

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Article information

DOI
https://doi.org/10.1039/C2RA21027D
Article type
Paper
Submitted
23 May 2012
Accepted
24 May 2012
First published
13 Jun 2012

RSC Adv., 2012,2, 7197-7206

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Palladium-catalysed direct regiospecific arylation at C5 of thiophenes bearing SO2R substituents at C3

C. B. Bheeter, J. K. Bera and H. Doucet, RSC Adv., 2012, 2, 7197 DOI: 10.1039/C2RA21027D

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