Issue 10, 2012
From the journal:

RSC Advances

Doxorubicin is a photocatalyst for the generation of H2O2†

Krzysztof Nawara,ab   Pawel Krysinskib  and  G. J. Blanchard*a  

* Corresponding authors

a Michigan State University, Department of Chemistry, East Lansing, MI, USA
E-mail: blanchard@chemistry.msu.edu
Tel: +1 517-355-9715 x224

b University of Warsaw, Department of Chemistry, Pasteura 1, Warsaw, Poland

Abstract

We have investigated the photoreactivity of the chemotherapeutic agent doxorubicin. We demonstrate the ability of this compound to generate H2O2 catalytically as a result of auto-oxidation of its photoreduced form. H2O2 may accumulate in toxic levels in pharmaceutical preparations.

Graphical abstract: Doxorubicin is a photocatalyst for the generation of H2O2

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Article information

DOI
https://doi.org/10.1039/C2RA20323E
Article type
Communication
Submitted
21 Feb 2012
Accepted
09 Mar 2012
First published
09 Mar 2012

RSC Adv., 2012,2, 4059-4061

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Doxorubicin is a photocatalyst for the generation of H2O2

K. Nawara, P. Krysinski and G. J. Blanchard, RSC Adv., 2012, 2, 4059 DOI: 10.1039/C2RA20323E

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