Issue 11, 2012
From the journal:

RSC Advances

Highly specific triple-fragment aptamer for optical detection of cocaine†

Ruxing Zou,‡a   Xinhui Lou,‡*a   Huichao Ou,‡b   Ying Zhang,a   Wenjie Wang,a   Min Yuan,cd   Ming Guan,a   Zhaofeng Luob  and  Yueying Liu*a  

* Corresponding authors

a Department of Chemistry, Capital Normal University, Xisanhuan North Rd. 105, Beijing, China
E-mail: xlou9999@yahoo.com
Fax: 8610 68902320
Tel: 8610 68902491-808

b University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Hefei 230027, China

c State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science, Changning Rd. 865, Shanghai, China

d Graduate School of the Chinese Academy of Sciences, Beijing, China

Abstract

For the first time an anti-cocaine aptamer was cut into three fragments, which were still able to specifically assemble with cocaine and render the sensitive and highly selective optical detection of cocaine. The assembly process possesses significantly different thermodynamic signature compared to the interactions involved monolithic aptamer and double-fragment aptamer.

Graphical abstract: Highly specific triple-fragment aptamer for optical detection of cocaine

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Article information

DOI
https://doi.org/10.1039/C2RA20307C
Article type
Communication
Submitted
20 Feb 2012
Accepted
26 Mar 2012
First published
26 Apr 2012

RSC Adv., 2012,2, 4636-4638

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Highly specific triple-fragment aptamer for optical detection of cocaine

R. Zou, X. Lou, H. Ou, Y. Zhang, W. Wang, M. Yuan, M. Guan, Z. Luo and Y. Liu, RSC Adv., 2012, 2, 4636 DOI: 10.1039/C2RA20307C

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