Issue 9, 2012
From the journal:

RSC Advances

Synthesis of 3,5-disubstituted pyrazolesvia cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine†

Shenghai Guo,*a   Jiliang Wang,a   Dongqiang Guo,a   Xinying Zhanga  and  Xuesen Fan*a  

* Corresponding authors

a School of Chemistry and Environmental Science, Henan Key Lab for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan, P. R. China
E-mail: shguo@htu.cn; xuesen.fan@htu.cn

Abstract

An efficient procedure for the synthesis of 3,5-disubstituted pyrazoles has been achieved through cyclocondensation reaction of 1,2-allenic ketones and hydrazines under extremely mild conditions. As an application, this methodology provides a highly efficient route to 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine.

Graphical abstract: Synthesis of 3,5-disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2RA20274C
Article type
Paper
Submitted
15 Feb 2012
Accepted
15 Feb 2012
First published
16 Feb 2012

RSC Adv., 2012,2, 3772-3777

Permissions

Request permissions

Synthesis of 3,5-disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine

S. Guo, J. Wang, D. Guo, X. Zhang and X. Fan, RSC Adv., 2012, 2, 3772 DOI: 10.1039/C2RA20274C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements