Issue 9, 2012
From the journal:

RSC Advances

Engineering of Brome mosaic virus for biomedical applications

Ibrahim Yildiz,a   Irina Tsvetkova,b   Amy M. Wen,a   Sourabh Shukla,a   M. Hema Masarapu,†b   Bogdan Dragneab  and  Nicole F. Steinmetz*c  

* Corresponding authors

a Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
E-mail: nicole.steinmetz@case.edu
Tel: +1 216-368-5590

b Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, USA

c Departments of Biomedical Engineering, Radiology, Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
E-mail: nicole.steinmetz@case.edu
Tel: +1 216-368-5590

Abstract

Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

Graphical abstract: Engineering of Brome mosaic virus for biomedical applications

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Article information

DOI
https://doi.org/10.1039/C2RA01376B
Article type
Paper
Submitted
30 Dec 2011
Accepted
18 Jan 2012
First published
23 Jan 2012

RSC Adv., 2012,2, 3670-3677

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Engineering of Brome mosaic virus for biomedical applications

I. Yildiz, I. Tsvetkova, A. M. Wen, S. Shukla, M. H. Masarapu, B. Dragnea and N. F. Steinmetz, RSC Adv., 2012, 2, 3670 DOI: 10.1039/C2RA01376B

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