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Issue 6, 2012

Synthesis, characterization and cytotoxicity study of magnetic (Fe3O4) nanoparticles and their drug conjugate

Author affiliations

Abstract

An easy synthesis of magnetic nanoparticles (Fe3O4) is described. Transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS) and X-ray diffraction (XRD) have been used to study the well dispersed and uniformly spherical nanoparticles. 5-Fluorouracil (5-FU) has been successfully loaded onto the nanoparticles and cytotoxicity studies were performed using a standard MTT assay. The results indicate that 5-fluorouracil-loaded iron nanoparticles are a more potent anticancer drugversus5-fluorouracil alone.

Graphical abstract: Synthesis, characterization and cytotoxicity study of magnetic (Fe3O4) nanoparticles and their drug conjugate

Article information


Submitted
17 Nov 2011
Accepted
11 Dec 2011
First published
02 Feb 2012

RSC Adv., 2012,2, 2493-2497
Article type
Paper

Synthesis, characterization and cytotoxicity study of magnetic (Fe3O4) nanoparticles and their drug conjugate

B. Banerji, S. K. Pramanik, S. Mandal, N. C. Maiti and K. Chaudhuri, RSC Adv., 2012, 2, 2493 DOI: 10.1039/C2RA01118B

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