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Issue 8, 2012
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Synthesis of a novel cellulose nanowhisker-based drug delivery system

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Abstract

Recently, cellulose nanowhiskers have attracted attention as a promising material in the biomedical field because of their outstanding properties such as hydrophilicity, biocompatibility, biodegradability, and high surface area. In this work, we prepared a novel nanometric carrier molecule for amine-containing biologically active molecules and drugs employing functionalized cellulose nanowhiskers. The nanowhiskers were grafted with a spacer molecule, gamma aminobutyric acid, using a periodate oxidation and Schiff's base condensation reaction sequence. To achieve controlled and rapid delivery of the targeting moiety, syringyl alcohol, a releasable linker, was then attached to it. All the reactions were carried out in aqueous media and the resulting products were characterized by FT-IR, NMR, XPS, and TEM experiments to evaluate the functional groups, structure, and morphology respectively.

Graphical abstract: Synthesis of a novel cellulose nanowhisker-based drug delivery system

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Article information


Submitted
13 Nov 2011
Accepted
12 Jan 2012
First published
28 Feb 2012

RSC Adv., 2012,2, 3403-3409
Article type
Paper

Synthesis of a novel cellulose nanowhisker-based drug delivery system

R. Dash and A. J. Ragauskas, RSC Adv., 2012, 2, 3403
DOI: 10.1039/C2RA01071B

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