Issue 2, 2012
From the journal:

RSC Advances

Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes†

Claude Chopard,*a   Gildas Berthoa  and  Thierry Prangéb  

* Corresponding authors

a Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, 45 rue des Sts Pères, cedex 06, Paris, France
E-mail: mailto:claude.chopard@parisdescartes.fr
Tel: +33 1 42 86 21 75

b Laboratoire de Cristallographie et RMN Biologiques, UMR 8015 CNRS, Université Paris Descartes, 4 avenue de l'Observatoire, cedex 06, Paris, France

Abstract

The scope of the biotransformation of a series of azaarene compounds by recombinant whole-cells of Escherichia coli JM109(DE3)(pDTG141) expressing the naphthalene dioxygenase system (NDOS) from Pseudomonas sp. NCIB 9616-4 was explored. The present study establishes that several bicyclic azaarenes are good substrates in the NDO-catalysed reaction, giving cis-dihydrodiol derivatives; monohydroxylated products were also observed.

Graphical abstract: Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1RA00706H
Article type
Paper
Submitted
09 Sep 2011
Accepted
13 Sep 2011
First published
15 Nov 2011

RSC Adv., 2012,2, 605-615

Permissions

Request permissions

Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes

C. Chopard, G. Bertho and T. Prangé, RSC Adv., 2012, 2, 605 DOI: 10.1039/C1RA00706H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements