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Issue 10, 2012
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pH-switchable polymer nanostructures for controlled release

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Abstract

A diblock copolymer consisting of poly(methyl acrylate) (PMA) and poly(pentafluorophenyl acrylate) (PPFPA) was synthesized by RAFT polymerization methods. The PPFPA block was then substituted with N,N-diisopropylethylenediamine and the end group modified with one of two hydrophilic groups to form pH-responsive copolymers. The self-assembly properties of these polymers were investigated and shown by TEM and DLS to form micelles at acidic pH and vesicles at basic pH. The encapsulation and controlled release of a hydrophilic dye molecule, Rhodamine B, was demonstrated using fluorescence spectroscopy.

Graphical abstract: pH-switchable polymer nanostructures for controlled release

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Publication details

The article was received on 20 Jul 2012, accepted on 08 Aug 2012 and first published on 09 Aug 2012


Article type: Paper
DOI: 10.1039/C2PY20545A
Citation: Polym. Chem., 2012,3, 3007-3015
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    pH-switchable polymer nanostructures for controlled release

    K. E. B. Doncom, C. F. Hansell, P. Theato and R. K. O'Reilly, Polym. Chem., 2012, 3, 3007
    DOI: 10.1039/C2PY20545A

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